CBGVa and CBGa: Cannabis has Two Powerhouse Precursor Molecules

CBGVa and CBGa: Cannabis has Two Powerhouse Precursor Molecules

Our beloved Cannabis Sativa plant matures into the most diverse and innovation-rich compounds imaginable. CBGVA serves as one of the pillars of cannabinoids, with researchers discovering new components therein. It's much like CBGa, in that it's a kingpin that creates a different type of cannabinoid known as "Varins". 

Let's delve deeper into the science to discover more about CBGVA. Also known as Cannabigerovarinic acid, CBGVA is a precursor of Cannabigerovarin (CBGV). It's naturally produced alongside (CBGA), another prevalent cannabinoid in the mature buds of the Cannabis Sativa plant.

Unlike stable and easy-to-come-by cannabinoids like CBD and THC, CBGVA, and other types of carboxylic acid cannabinoid precursors such as CBGa, they have somewhat unstable molecular structures that change under heat. Thus Raw Cannabis majorly contains carboxylic acids instead of stable cannabinoids.

CBGVA's prominence comes from its role as a precursor cannabinoid. Enzymatic processes transform it into different composition forms, like other carboxylic acid cannabinoids.

It was discovered in 1977 by Japanese researchers CBGV was isolated alongside other cannabinoid acids like THCVA, CBDVA, and CBCVA. Its versatility led researchers to confirm a set of discoveries years later.

It is a precursor of varin cannabinoids, a subset of cannabinoids that have yet to be studied as much as our mainstay cannabinoids, such as THC or CBD. Nevertheless, THCVA has undergone heavier research compared to the other varin cannabinoids.

While the potential of CBGVA in anti-inflammatory and anti-cancer effects is quite significant, using it isn't easy. Natural Asian cannabis strains have a concentration of CBGVA placed near 1%, which requires selective breeding for higher concentrations in Research and Development. Unfortunately, these strains aren't publicly available.

Varin molecules such as CBGVa, technically called varinolic cannabinoids, are slowly beginning to be included in commercial hemp and cannabis product formulations. The most popular varin cannabinoids are CBCV, CBDV, CBGV, and THCV. 

Different families of cannabinoid compounds feature varying chemical structures. Varin molecules have three carbon atoms in their alkyl side chain, while neutral versions of cannabinoids feature five carbon atoms. The newly discovered phoral family of cannabinoids identified in 2019 by Italian researchers, including CBDP and THCP, features seven side-chain carbon atoms. 

The molecular structure of these phyto-molecules is essential because it changes their binding affinity. Binding affinity determines these molecules' potency and other characteristics when they "dock" with microscopic cellular receptors within the endocannabinoid system (including CB1, CB2, and the GPRs).

Of note is that no varin is a scheduled substance by the U.S. federal government. Companies considering product formulations involving varin cannabinoids can infuse them into their products without fear of legal repercussions, but many are sure this won't last long. 

However, whatever we discover about CBGVA with time will help us extend our knowledge of other cannabinoids like THCV and CBDV. But we still know very little about this cannabinoid, which is what we need to continue gathering more information.

Before we conclude, let's shine a light on CBGa crumble - a consumption product with CBGa as one of its main components. CBGa crumble is a form of concentrate that is created by purifying CBGa. Its high concentration ensures the potency of cannabinoids without any of the psychoactive effects.

Many consumers find that using CBGa and other Cannabinoids allows them to create a better, more productive, and efficacious protocol to keep them happy. 

Many reports from consumers are that of increased energy when using the varin cannabinoids THCV. These are strikingly similar statements from consumers about how CBGa ingestion energizes them, giving them more artistic abilities and an excellent metabolic boost while doing much of what THC and CBD do for them. 

Both give the user a desire to get something done other than eat and kick back - that's what these precursor molecules, like CBGVa and CBGa, do for users. This is incredible for the average consumer when you couple it with the other plant extracts used, as it gives balance - something our Endocannabinoid System desires. 

That anecdotal input shows the striking similarities between the offspring of CBGVa compared to CBGa, with both precursor molecules that create all cannabinoids exerting magnificent power within our bodies. 

One of the best things consumers love about using CBGa Crumble is it makes them happy.

When we look at the power of these precursor molecules in the plant, creating the balance of cannabinoids, it's not surprising that CBGVa and CBGa are the all-stars in the world of Cannabis because, without them, there wouldn't be so many therapeutic constituents so many love, like THC, CBD, and CBN. 

Thank you for visiting the CBGa Crumble Blog. 

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